Petite summer lin magnet
Tsai TW, Fang JL, Liang CY, Wang CJ, Huang YT, Wang YJ, Li JY, (Yu CC)* (2019-12) ACS Catalysis 9(12) 10712−10720 “Exploring the Synthetic Application of Helicobacter pylori α1,3/4-Fucosyltransferase FucTIII toward the Syntheses of Fucosylated Human Milk Glycans and Lewis Antigens.”.Huang HH, Fang JL, Wang HK, Sun CY, Tsai TW, Huang YT, Kuo CY, Wang YJ, Liao CC, (Yu CC)* (2019-12) ACS Catalysis 9(12), 11794−11800 “Substrate Characterization of Bacteroides fragilis α1,3/4-Fucosyltransferase Enabling Access to Programmable One-Pot Enzymatic Synthesis of KH 1 Antigen.”.Liou SW, Fang JL, Lin HW, Tsai TW, Huang HH, Liang CY, Yang, CR, Wei GT*, (Yu CC)* (2021-03) Chemistry – An Asian Journal 16(5), 492–497 “Effective separation of human milk glycosides using carbon dioxide supercritical fluid chromatography.”.Huang YT, Su YC, Wu HR, Huang HH, Lin EC, Tsai TW, Tseng HW, Fang JL, (Yu CC)* (2021-03) ACS Catalysis 11(5), 2631−2643 “Sulfo-Fluorous Tagging Strategy for Site-Selective Enzymatic Glycosylation of para-Human Milk Oligosaccharides.”.Pao YP, (Yu CC), Lin YZ, Chatterjee S, Saha S, Tiwari N, Huang YT, Wu CC*, Choi D*, Lin ZH* (2021-07) Nano Energy 85, 106008 “Carbohydrate-Protein Interactions Studied by Solid-Liquid Contact Electrification and its Use for Label-Free Bacterial Detection.”.Ooi KE, Zhang XW, Kuo CY, Liu YJ, (Yu CC)* (2022-05) Frontiers in Chemistry 10, 905105 “Chemoenzymatic Synthesis of Asymmetrically Branched Human Milk Oligosaccharide Lacto-N-Hexaose.”.Specific systems of interest are: 1) Discovering new enzymes as biocatalysts for human milk-type glycan synthesis 2) Chemoenzymatic synthesis of the human milk oligosaccharide library and 3) The function of human milk oligosaccharides in human gut microbiota and to investigate their roles in preventing the pathogenic infections. The major area of focus is human milk glycans. My underlying research philosophy is to work on problems in which developing methods for preparing novel, structurally-interesting glycans leads to tools for studying vital biological problems. The long-term goals of our research program are to develop state-of-the-art methods for assembling complex, biologically-relevant carbohydrates (glycans) that can be used to probe their function in nature. Students and postdoctoral fellows in the group use synthetic chemistry and enzymatic strategy to prepare compounds with interesting biological activities and then have the opportunity to use them in either biochemical or conformational studies.
Our research program is focused in the areas of biosynthetic chemistry (with a particular emphasis in enzymatic carbohydrate synthesis), the structure determination/analysis of oligosaccharides and the discovery of novel carbohydrate-active enzymes that can be used in complex oligosaccharide synthesis.
Mammalian cell-based recombinant protein expression.Personal Information Protection Act Disclosure.